“2-Benzylidene-2,3-dihydro-1H-inden-1-one” derivatives, is a bicyclic carbonyl compound possessing interesting biological activities i.e., mast cell stabilizing, anticoagulant, acetyl choline esterase inhibition, anti-inflammatory, anti-cancer, anti-malarial and antibacterial activities. Benzylidene substituted 9 Indanone derivatives have been synthesized. The structures of the newly synthesised compounds were established by spectroscopic interpretation (1H NMR, 13C NMR, Mass and IR spectra) studies. Melting range of the synthesised compounds, percentage yield, Rf value, molecular formula, molecular weights were established. After final structural confirmation the synthesized compounds were evaluated for antithrombotic activity.
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